The DynaCHIP technology is based upon a novel microfluidic chip design that exponentially accelerates sample clean up and conditioning for real-time electrospray ionization mass spectrometry (ESI-MS) analysis.

Ultra-High ThroughputSample-Prep Technology

Sample preparation is the current bottleneck for modern mass spectrometry. The DynaCHIP is a micro-mass exchanger utilizing tangential flow filtration for active sample conditioning in a flow-through configuration with a sample residence time of just 1-second.

The microfluidic chip is manufactured via advanced microfabrication that allows for scalable and reproducible production of the device. This ensures easy and repeatable sample prep every time.


In “standard operation,” the device utilizes a novel “active sample treatment” to optimize complex biochemical samples for ESI-MS. It optimizes the signal to noise ratio by conditioning the sample via:

Selective removal of deleterious chemicals, e.g., salts
Enabling retention of critical large weight biomolecules
Infusing proprietary signal enhancing chemicals
“Active Sample Treatment"

High Throughput Mass Spec Analysis

1 sec
Extract Sample
1 sec
DynaCHIP Rapid
Sample Prep
3 min
Plug and Play:
Benchtop Device
Mass Spec Inteface
15 min
DynaData ML:
Feedback Control
Cell-State Analysis

Drop-In Integration

DynaCHIP enables measurements of the biomolecules that matter most.